A New Cyanoacrylate Colloidal Polymer with Novel Antibacterial Mechanism and Its Application to Infection Control

The cyanoacrylate polymer particles, which do not contain antibiotics or antibacterial agents, bond with the cell wall of drug-resistant bacteria, and then induced an auto-destructive behavior that causes the bacteria to destroy itself. Because of this, the drug-resistant bacteria are unable to arise. One noteworthy point of this nano-polymer is that it excels in safety given its induction of bacteria auto-destruction. The raw ingredients of this polymer consist only of biodegradable acrylic adhesives used in clinical practice and saccharides; thus, there have been no observed side effects in oral administration, tail vein administration, celiac administration, or intramuscular administration in mice. In this way, there are no other antibacterial agents that are superior to our nano-polymer in terms of safety given this antibacterial mechanism. *Corresponding author: Shoichi Shirotake, Department of PharmacoTherapeutics, Yokohama City University, Japan, Tel: +81-45-787-2705; Fax: +8145-787-2707; E-mail: [email protected] Received October 30, 2013; Accepted Janaury 20, 2014; Published Janaury 23, 2014 Citation: Shirotake S (2014) A New Cyanoacrylate Colloidal Polymer with Novel Antibacterial Mechanism and Its Application to Infection Control. J Nanomedine Biotherapeutic Discov 4: 122. doi:10.4172/2155-983X.1000122 Copyright: © 2014 Shirotake S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Antimicrobial drugs acting extracellularly i. Cell wall synthesis inhibitors Beta-lactams (penicillin, cephem, carbapenem, and monobactam) ii. Cell membrane dysfunction drugs Cyclic peptides (polymixin and bacitracin) Antimicrobial drugs acting intracellularly iii. Nucleic acid dysfunction drugs: Quinolones and rifamycin iv. Protein synthesis inhibitors:Macrolides, tetracycline, aminoglycosides and chloramphenicol v. Folic acid synthesis inhibitor: Sulfa drugs, trimethoprim and ST combination drug Table 1: Classification of major antimicrobial drugs by mechanism of action. Citation: Shirotake S (2014) A New Cyanoacrylate Colloidal Polymer with Novel Antibacterial Mechanism and Its Application to Infection Control. J Nanomedine Biotherapeutic Discov 4: 122. doi:10.4172/2155-983X.1000122